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After 24 hours, we collected blood samples and liver tissues from the animals to assess the liver's response. The results were promising: we found that serum markers indicating liver damage, such as ALT, AST, and ALP, were significantly elevated in the mice treated with cyclophosphamide alone. However, those receiving oregano extract showed a marked reduction in these markers, suggesting that oregano may help protect the liver from poisoning caused by chemotherapy.
The histological examinations aligned with these findings and confirmed that oregano extract has protective properties against liver damage. With its rich array of flavonoids and phenolic compounds, oregano seems capable of supporting liver health during challenging treatments. Thus, incorporating oregano may offer a supportive approach to mitigate the side effects of chemotherapy on the liver.
In our study, we found that didymin significantly reduced indicators of liver injury in mice, including levels of important liver enzymes like ALT and AST. Furthermore, treatment with didymin led to lower levels of toxic substances and inflammatory markers in the liver, while boosting the activity of antioxidant enzymes that protect the liver from damage.
We also observed that didymin effectively inhibited key signaling pathways involved in inflammation, specifically the NF-κB and MAPK pathways. Impressively, didymin increased the expression of a protein known as RKIP, which plays a critical role in protecting liver cells. It was interesting to note that when we inhibited RKIP specifically, the protective effects of didymin were diminished.
Overall, our findings suggest that didymin from oregano holds promise in alleviating liver injury, primarily through its antioxidant properties and its ability to regulate inflammatory responses in the liver.
Throughout the study, we measured key indicators of liver function, including enzymes in the serum, the levels of lipid peroxides, and antioxidant markers in liver tissues. We found that CCl4 led to clear signs of liver injury, but the administration of oregano extract showed significant protective effects. This improvement was most pronounced at the highest dose of 150 mg/kg.
Our analyses revealed that oregano not only helped in reducing liver enzyme levels indicative of damage but also boosted antioxidant activity in the liver. Histopathological examinations aligned with these biochemical improvements, indicating healthier liver cells after treatment with oregano. This study suggests that oregano could be a valuable ally in protecting against liver toxicity.
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After 24 hours, we collected blood samples and liver tissues from the animals to assess the liver's response. The results were promising: we found that serum markers indicating liver damage, such as ALT, AST, and ALP, were significantly elevated in the mice treated with cyclophosphamide alone. However, those receiving oregano extract showed a marked reduction in these markers, suggesting that oregano may help protect the liver from poisoning caused by chemotherapy.
The histological examinations aligned with these findings and confirmed that oregano extract has protective properties against liver damage. With its rich array of flavonoids and phenolic compounds, oregano seems capable of supporting liver health during challenging treatments. Thus, incorporating oregano may offer a supportive approach to mitigate the side effects of chemotherapy on the liver.
Throughout the study, we measured key indicators of liver function, including enzymes in the serum, the levels of lipid peroxides, and antioxidant markers in liver tissues. We found that CCl4 led to clear signs of liver injury, but the administration of oregano extract showed significant protective effects. This improvement was most pronounced at the highest dose of 150 mg/kg.
Our analyses revealed that oregano not only helped in reducing liver enzyme levels indicative of damage but also boosted antioxidant activity in the liver. Histopathological examinations aligned with these biochemical improvements, indicating healthier liver cells after treatment with oregano. This study suggests that oregano could be a valuable ally in protecting against liver toxicity.
Remarkably, we observed a reduction in harmful substances like cholesterol and triglycerides, alongside an increase in beneficial high-density lipoprotein. This indicates a positive shift in the mice's overall liver health. Additionally, the fat accumulation in the liver decreased notably, which is a key factor in non-alcoholic fatty liver disease.
Furthermore, we examined the expression of certain genes related to fat metabolism and discovered that their activity went down significantly in the mice that received oregano treatment. This suggests that oregano may help regulate how the body processes fats, potentially leading to better management of obesity and fat-related liver issues.
The calves that received essential oils showed a positive trend in body weight compared to the control group. We observed notable improvements in their blood parameters, including higher leukocyte counts and lower levels of certain liver enzymes, suggesting that oregano may help reduce liver stress. This group also exhibited lower oxidative stress markers and reduced inflammation as indicated by lower serum levels of haptoglobin and C-reactive protein.
In contrast, the control group displayed signs of liver stress and inflammation upon analysis. Our findings indicate that oregano, alongside other essential oils, could mitigate the negative effects of trichothecenes on liver health in calves, serving as a potential aid in improving overall animal wellbeing and health resilience.
We analyzed the chemical makeup of oregano's hexane extract, identifying 25 different compounds, with prominent elements like cholesten-3-one and gamma-tocopherol. To test its effectiveness, we divided the rats into seven groups: a control group, groups receiving different doses of oregano, and groups treated with thioacetamide (TAA), which induces HE.
Throughout the study, we measured various outcomes, including behavior changes, body weight, and blood markers. TAA caused anxiety and cognitive impairments in the rats, alongside significant weight changes and liver stress. Remarkably, treatment with oregano significantly improved these symptoms, showcasing its potential as a hepato- and neuroprotective agent.
We found that oregano’s protective effects were comparable to those of silymarin, a standard liver treatment. Both treatments helped mitigate the damaging effects of TAA on the liver and brain, suggesting that oregano could be an excellent alternative in supporting liver health and function.
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Frequently Asked Questions
Liver disease encompasses a variety of conditions that affect the liver's ability to function effectively. The liver is a vital organ responsible for many important tasks, including metabolizing nutrients, detoxifying harmful substances, and producing bile for digestion. Common forms of liver disease include hepatitis, fatty liver disease, cirrhosis, and liver cancer. Each of these conditions can significantly impact liver function and overall health, leading to symptoms that range from fatigue and jaundice to more serious complications requiring urgent medical attention.
The causes of liver disease are diverse and can include chronic alcohol abuse, viral infections, autoimmune disorders, and metabolic conditions like obesity and diabetes. Early detection is key to managing liver disease effectively, often involving lifestyle changes, medications, and sometimes surgical interventions. Regular check-ups and liver function tests are recommended for individuals at higher risk, such as those with a family history of liver disease or those who lead certain lifestyle habits. Adopting a balanced diet and reducing alcohol intake can greatly aid in liver health and help prevent the onset of these conditions.
Oregano oil supplements are nutritional products derived from the leaves and flowers of the oregano plant, primarily Origanum vulgare. Known for their potent antioxidant and antimicrobial properties, these supplements are often used to support immune health, aid digestion, and combat infections. Oregano oil is rich in compounds like carvacrol and thymol, which are believed to contribute to its therapeutic effects. They come in various forms, including softgels, capsules, and liquid extracts, making it easy for anyone to incorporate them into their daily routine.
When considering oregano oil supplements, it's important to choose high-quality products that provide standardized amounts of active ingredients. The recommended dosage can vary based on individual health needs, so it’s always wise to consult a healthcare professional before starting any new supplement regimen. Overall, oregano oil supplements can be a convenient way to harness the health benefits associated with this aromatic herb, but users should remain informed about potential interactions and side effects, particularly regarding dosage and individual health conditions.
Users report varying timelines when it comes to seeing results from this supplement for liver disease, with some experiencing benefits fairly quickly. For instance, one user noted improvements in their liver and gallbladder health almost immediately, indicating that they felt the benefits relating directly to their liver disease shortly after starting the supplement (Read Review). Another user mentioned feeling more energetic and observing positive effects on their liver disease, implying that noticeable changes can occur within a similar timeframe (Read Review).
Oregano has shown promising potential as a supportive supplement for liver health, with several studies highlighting its benefits across various contexts. For instance, research has demonstrated that oregano seed extract can significantly improve liver enzyme levels and reduce fat accumulation in the liver, which is crucial in managing non-alcoholic fatty liver disease in mice [1]. Additionally, oregano oil has been observed to provide protective effects against liver injury caused by harmful substances like carbon tetrachloride, indicating its role in improving liver function and reducing cellular damage [2].
Further studies have revealed that oregano may offer antioxidant benefits and help regulate genes involved in fat metabolism, which could be applicable in managing liver diseases [5]. This herb's defensive mechanisms include reducing liver enzyme levels associated with damage and promoting overall liver wellness in animal models [14]. Thus, while research is still ongoing and primarily conducted in animal models, the evidence points to oregano as a compelling natural candidate for supporting liver health.
Based on user reviews, many individuals report significant improvements in their symptoms related to liver disease and overall well-being after using this supplement. Specifically, one user expressed that they experienced a noticeable boost to their liver and gallbladder health, indicating a sense of cleansing and overall benefit shortly after starting the supplement (Read Review). Another reviewer emphasized feeling more energetic while noting positive effects on both their liver condition and general immunity, suggesting that the supplement might also help combat infections effectively (Read Review).
Besides liver-specific benefits, users have mentioned improvements in immune function, which can be crucial for those with underlying health issues, such as rheumatism (Read Review). While these anecdotal experiences highlight the potential effectiveness of the supplement, it's essential to remember that individual results can vary widely depending on personal health conditions and circumstances.
Based on user reviews, there seems to be a consensus that Oregano Oil Supplements can positively impact liver health, though specific dosages are not detailed. Users reported beneficial effects for their liver conditions, with one individual noting, "It helps my liver and gallbladder" and mentioning they noticed improvements while cleansing their body related to liver disease (Read Review). Another reviewer remarked that they felt more energetic and noted improvements in their liver health alongside overall immunity (Read Review).
While these reviews highlight the positive effects of oregano oil on liver diseases, they do not specify an exact dosage that users found effective. Users have emphasized that the oil is high quality and effective for various immune-related issues, which could suggest that the right dose may vary based on individual needs and health conditions (Read Review). As always, it's advisable to consult with a healthcare professional for personalized dosage recommendations.
Remarkably, we observed a reduction in harmful substances like cholesterol and triglycerides, alongside an increase in beneficial high-density lipoprotein. This indicates a positive shift in the mice's overall liver health. Additionally, the fat accumulation in the liver decreased notably, which is a key factor in non-alcoholic fatty liver disease.
Furthermore, we examined the expression of certain genes related to fat metabolism and discovered that their activity went down significantly in the mice that received oregano treatment. This suggests that oregano may help regulate how the body processes fats, potentially leading to better management of obesity and fat-related liver issues.
CCl is known for causing severe liver injury, leading to problems like reduced protein synthesis and hematological disorders, such as changes in red and white blood cell counts. Our findings revealed that both doses of oregano oil provided protective effects on the liver. We observed improvements in protein synthesis and liver function markers, while also noting a reduction in the cytogenetic changes that typically occur in liver cells following CCl exposure.
Interestingly, the high dose of oregano oil was particularly effective in protecting red blood cells, though its impact on hemoglobin production was less pronounced. We also noticed that while the higher dose helped reduce white blood cell and lymphocyte counts, this could potentially weaken the immune response. However, it showed improved efficacy against thrombocytosis, or increased platelet aggregation.
Overall, our study suggests that oregano oil may serve as a beneficial treatment option for liver injury, balancing its protective benefits against some potential downsides associated with higher doses.
We performed deep RNA sequencing on high-quality samples, leading to an impressive average of 113.3 million sequences per sample. Our findings revealed that oregano has a significant impact on liver gene expression, particularly regarding the regulation of steroid hormones and the metabolism of fats and carbohydrates.
Notably, oregano supplementation influenced the host's disease profile, showing the capacity to alter the transcriptional effects of various registered drugs. Importantly, it demonstrated a potential to inhibit transcription related to several cancer categories, including liver cancer. Overall, our observations indicate that oregano could serve as a powerful natural alternative in managing liver health and mitigating disease risks.
After 24 hours, we collected blood samples and liver tissues from the animals to assess the liver's response. The results were promising: we found that serum markers indicating liver damage, such as ALT, AST, and ALP, were significantly elevated in the mice treated with cyclophosphamide alone. However, those receiving oregano extract showed a marked reduction in these markers, suggesting that oregano may help protect the liver from poisoning caused by chemotherapy.
The histological examinations aligned with these findings and confirmed that oregano extract has protective properties against liver damage. With its rich array of flavonoids and phenolic compounds, oregano seems capable of supporting liver health during challenging treatments. Thus, incorporating oregano may offer a supportive approach to mitigate the side effects of chemotherapy on the liver.
References
- Lee HJ, Bae JY, Park KW, Kim MJ. Ethyl acetate fraction of oregano seed protects non-alcoholic fatty liver in high-fat diet-induced obese mice through modulation of . Food Sci Nutr. 2024;12:2578. doi:10.1002/fsn3.3939
- Suljević D, Fočak M, Škrijelj R, Mitrašinović-Brulić M. Therapeutic benefit of oregano oil in the acute idiosyncratic hepatotoxicity induced by carbon tetrachloride in rats: Adverse effects of high dose of oreganum. Cell Biochem Funct. 2024;42:e4015. doi:10.1002/cbf.4015
- Machado M, Nora L, Zanin TBN, Bissacotti BF, Morsch VM, et al. Impacts of intake of trichothecenes (Fusarium sporotrichioides) for dairy calves: Effects on animal growth, oxidative and inflammatory response. Microb Pathog. 2024;190:106605. doi:10.1016/j.micpath.2024.106605
- Abdelghffar EAR, El-Nashar HAS, Fayez S, Obaid WA, Eldahshan OA. Ameliorative effect of oregano (Origanum vulgare) versus silymarin in experimentally induced hepatic encephalopathy. Sci Rep. 2022;12:17854. doi:10.1038/s41598-022-20412-3
- Bajagai YS, Radovanovic A, Steel JC, Stanley D. The Effects of Continual Consumption of on Liver Transcriptomics. Animals (Basel). 2021;11. doi:10.3390/ani11020398
- Khafaga AF, Naiel MAE, Dawood MAO, Abdel-Latif HMR. Dietary Origanum vulgare essential oil attenuates cypermethrin-induced biochemical changes, oxidative stress, histopathological alterations, apoptosis, and reduces DNA damage in Common carp (Cyprinus carpio). Aquat Toxicol. 2020;228:105624. doi:10.1016/j.aquatox.2020.105624
- Pasavei AG, Mohebbati R, Boroumand N, Ghorbani A, Hosseini A, et al. Anti-Hypolipidemic and Anti-Oxidative Effects of Hydroalcoholic Extract of on the Hepatosteatosis Induced with High-Fat Diet in Rats. Malays J Med Sci. 2020;27:57. doi:10.21315/mjms2020.27.1.6
- Oniga I, Pușcaș C, Silaghi-Dumitrescu R, Olah NK, Sevastre B, et al. ssp. : Chemical Composition and Biological Studies. Molecules. 2018;23. doi:10.3390/molecules23082077
- Aralbaeva AN, Mamataeva AT, Zhaparkulova NI, Utegalieva RS, Khanin M, et al. A composition of medicinal plants with an enhanced ability to suppress microsomal lipid peroxidation and a protective activity against carbon tetrachloride-induced hepatotoxicity. Biomed Pharmacother. 2017;96:1283. doi:10.1016/j.biopha.2017.11.085
- Huang Q, Bai F, Nie J, Lu S, Lu C, et al. Didymin ameliorates hepatic injury through inhibition of MAPK and NF-κB pathways by up-regulating RKIP expression. Int Immunopharmacol. 2017;42:130. doi:10.1016/j.intimp.2016.11.028
- Wei J, Huang Q, Bai F, Lin J, Nie J, et al. Didymin induces apoptosis through mitochondrial dysfunction and up-regulation of RKIP in human hepatoma cells. Chem Biol Interact. 2017;261:118. doi:10.1016/j.cbi.2016.11.026
- Fathy SA, Emam MA, Abo Agwa SH, Abu Zahra FA, Youssef FS, et al. The antiproliferative effect of Origanum majorana on human hepatocarcinoma cell line: suppression of NF-κB. Cell Mol Biol (Noisy-le-grand). 2016;62:80.
- Aristatile B, Al-Assaf AH, Pugalendi KV. Carvacrol ameliorates the PPAR-A and cytochrome P450 expression on D-galactosamine induced hepatotoxicity rats. Afr J Tradit Complement Altern Med. 2014;11:118.
- Habibi E, Shokrzadeh M, Chabra A, Naghshvar F, Keshavarz-Maleki R, et al. Protective effects of Origanum vulgare ethanol extract against cyclophosphamide-induced liver toxicity in mice. Pharm Biol. 2015;53:10. doi:10.3109/13880209.2014.908399
- Sikander M, Malik S, Parveen K, Ahmad M, Yadav D, et al. Hepatoprotective effect of Origanum vulgare in Wistar rats against carbon tetrachloride-induced hepatotoxicity. Protoplasma. 2013;250:483. doi:10.1007/s00709-012-0431-5
- Shati AA. Effects of Origanum majorana L. on cadmium induced hepatotoxicity and nephrotoxicity in albino rats. Saudi Med J. 2011;32:797.
